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Mice were randomized in different treatment groups: control ( n = 4), RT ( n = 3), sertraline ( n = 4) and the combination of sertraline and RT ( n = 4)

Cobalamin deficiency: clinical picture and radiological findings. Nutrients 5.11 (2013): 4521-4539

Several experiments now suggest that inhibition of cellular pyroptosis through glycolytic pathway intervention is some of the therapeutic tools for joint diseases, where TRPV4 mediated mitochondrial dysfunction could induce cellular pyroptosis and cartilage degradation in osteoarthritis through the Drp1- HK2 axis (170)

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20 Rajman L, Chwalek K, Sinclair DA